09/26/2011 - Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia.

posted Oct 10, 2011, 1:41 PM by Chief Resident   [ updated Oct 10, 2011, 1:41 PM by David de Gijsel ]
This week, we'll take a look at the treatment of sickle cell anemia. You've all had your share of patients with sickle cell crises, I suppose. I know that some of you only knew this disease from the text book before you came to Monte. As with many diseases, the subset of patients you encounter in the hospital is quite different from the average patient that's affected and often times, they're quite challenging to manage. To balance your view on sickle cell anemia, we picked an article that presents a major breakthrough in the treatment of this disease. 

The attached paper 'Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia' is the original RCT that established the efficacy of this treatment. I also attached a second paper, 'The risks and benefits of long-term use of hydroxyurea in sickle cell anemia', which is a follow-up study of the original cohort, but for journal club, we'll focus on the first one.
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