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Resident Inpatient Journal Club

3/22/2012 - Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale

posted Mar 19, 2012, 10:15 AM by David de Gijsel

This study is a nice example of the difference between association and causality and answers a lingering question in the treatment of cryptogenic stroke in a randomized, controlled fashion.

3/8/2012 - Venous Thromboembolism Prophylaxis in Hospitalized Medical Patients and Those With Stroke

posted Mar 7, 2012, 10:19 AM by David de Gijsel

Let's revisit a very relevant topic to our care of patients in the hospital: DVT prophylaxis in hospitalized medical patients. You'll learn some interesting facts!

While the guidelines are useful and very practical, we will look at the second paper, which is a review and meta-analysis that provided the evidence base for the guidelines. Don't be intimidated by it's size: it's 27 pages long, but 16 of these are references and appendices!

3/1/2012 - Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths

posted Feb 29, 2012, 10:02 AM by David de Gijsel

Although a bit of an outpatient topic, I thought we'd take a look at 'Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths' from this week's NEJM:

1. It got a lot of press.
2. It was ridiculed in last week's Grand Rounds.
3. It has some great methodological flaws.
4. It does evaluate an outcome we like (in studies, at least): death

2/21/2012 - Vitamin D Therapy and Cardiac Structure and Function in Patients With Chronic Kidney Disease

posted Feb 29, 2012, 9:57 AM by David de Gijsel   [ updated Feb 29, 2012, 9:57 AM ]

We'll take a look at 'Vitamin D Therapy and Cardiac Structure and Function in Patients With Chronic Kidney Disease: The PRIMO Randomized Controlled Trial' from this week's JAMA. It's an interesting trial both for its role in the ongoing debate about the role of Vitamin D in cardiovascular health as well as for it's methodology, including the fact that despite its being a 'negative' trial, it was published in a major journal.

10/19/2011 - Prevention of HIV-1 Infection with Early Antiretroviral Therapy

posted Oct 15, 2011, 8:07 AM by Chief Resident

After Uri Felsen's noon conference on HIV testing, I thought we could take at what likely will be a landmark paper: the first RTC that looks at early ART as prevention of HIV infection.

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