Critical Care Medicine

1. Initial Trophic vs Full Enteral Feeding in Patients With Acute Lung Injury The EDEN Randomized Trial (2012)

    • Do various methods of tube feeding patients admitted to the ICU affect outcomes?

8. Goal-Directed Resuscitation for Patients with Early Septic Shock (2014)

    • Does early goal-directed care affect mortality inpatients presenting to the ER with septic shock?

2a. Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (1995)

    • Does NIPPV (i.e. BIPAP) reduce the risk of intubation?

9. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis (2017)

    • Does a 3-hour sepsis order set reduce mortality?

2b. Noninvasive versus invasive ventilation in COPD patients with severe acute respiratory failure deemed to require ventilatory assistance (2004)

    • Does NIPPV (i.e. BIPAP) reduce the risk of intubation?
    • Does NIPPV (i.e. BIPAP) reduce morbidity and mortality?

10a. Balanced Crystalloids vs Saline in Non-critically Ill Adults (SMART, 2018)

    • Does use saline versus balanced crystalloid solution affect mortality in non-critically ill adults?

3a. Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome (2000)

    • Does low versus traditional tidal volumes reduce morbidity or mortality in patients with acute respiratory distress syndrome?

10b. Balanced Crystalloids vs Saline in Critically Ill Adults (SALT-ED, 2018)

    • Does use saline versus balanced crystalloid solution affect mortality in critically ill adults?

3b. Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome (2004)

    • Does low versus higher PEEP reduce morbidity or mortality in patients with acute respiratory distress syndrome?

11a. Adjunctive Glucocorticoid Therapy in Patients with Septic Shock (ADRENAL, 2018)

    • Do glucocorticoids reduce mortality in patients with septic shock?

4. A Comparison of Four Methods of Weaning Patients From Mechanical Ventilation (1995)

    • What is the most effective method to wean a patient from a ventilator?

11b. Hydrocortisone + Fludrocortisone for Adults with Septic Shock (APROCCHSS, 2018)

    • Do glucocorticoids combined with mineralocorticoids reduce mortality in patients with septic shock?

5a. Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation on Reintubation and Postextubation Respiratory Failure in High-Risk Patients: A Randomized Clinical Trial (2016)

    • Is post-extubation HFNC non-inferior to NIPPV?

12a. Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock (VASST, 2008)

    • Does vasopressin reduce mortality in patients with septic shock when compared to norepinephrine?

5b. Effect of Postextubation High-Flow Nasal Cannula vs Conventional Oxygen Therapy on Reintubation in Low-Risk Patients: A Randomized Clinical Trial (2016)

    • Is the use of HFNC superior to traditional nasal cannula in preventing post-extubation complications?

12b. Comparison of Dopamine and Norepinephrine in the Treatment of Shock (SOAP-II, 2010)

    • Does vasopressin reduce mortality in patients with septic shock when compared to dopamine?

6. Heparin Plus Alteplase Compared with Heparin Alone in Patients with Submassive Pulmonary Embolism (2002)

    • Does heparin + tPA reduce morbidity or mortality when compared to heparin alone?

13a. a. A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care (TRICC, 1999)

    • Does a restrictive vs liberal transfusion strategy affect mortality?

7a. Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol (2012)

    • Does daily sedation interruption affect duration of ventilation or ICU stay?

13b. Transfusion Strategies for Acute Upper Gastrointestinal Bleeding (2013)

    • Does a restrictive vs liberal transfusion strategy affect mortality in patients with acute upper GI bleeding?

7b. Randomized trial of light versus deep sedation on mental health after critical illness (2009)

    • Does light versus deep sedation affect duration of ventilation or mortality?

13c. Lower versus Higher Hgb Threshold for Transfusion in Septic Shock (TRISS, 2014)

    • Does a low versus high hemoglobin transfusion target strategy affect mortality in patients with septic shock?