Does intensive medical therapy (A1C 7.0) improve microvascular and macrovascular outcomes when compared to standard lifestyle interventions alone (A1C 7.9) in patients with type 2 diabetes?
Does treatment of osteoporosis with annual zolendronic acid infusions reduce fracture risk in postmenopasual women?
After 10 years of therapy, does intensive medical therapy improve macrovascular outcomes when compared to standard lifestyle interventions alone in patients with type 2 diabetes?
After receiving zolendronic acid for the treatment of osteoporosis for 3 years, is there any additional benefit from extension of therapy to a total of 6 years in postmenopasual women?
Does intensive insulin therapy (3+ injections) improve microvascular outcomes when compared to conventional insulin therapy (1-2 injections) in patients with type 1 diabetes?
Does RANK ligand inhibition with denosumab decrease risk of fractures in women with osteoporosis?
Does intensive insulin therapy improve macrovascular outcomes when compared to conventional insulin therapy in patients with type 1 diabetes?
New Zealand Osteopenia Trial
Does treatment of osteopenia with bisphosphonates decrease risk of fractures in postmenopausal women?
In critically ill, hospitalized patients with type 2 diabetes, is intensive blood glucose control (81-108) superior to conventional blood glucose control (< 180)?
Do corticosteroids improve survival or increase the likelihood of shock reversal in patients with septic shock?
In non-critically ill, hospitalized patients with type 2 diabetes, is a basal-bolus insulin regimen superior to a sliding scale insulin regimen?
Tolvaptan for Hyponatremia
Does vasopressin V2-receptor antagonism with tolvaptan improve hyponatremia in patients with CHF, cirrhosis, or SIADH?
Does GLP-1 agonism with liraglutide improve cardiovascular outcomes in patients with type 2 diabetes?
Does SGLT2 inhibition with empagliflozin improve cardiovascular outcomes in patients with type 2 diabetes?
Chronic Autoimmune Thyroiditis Review
In patients with type 2 diabetes and a BMI greater than 27, does surgical weight loss provide superior glycemic control compared to medical therapy alone?
Graves’ Disease Review
In patients with insulin resistance but without diabetes who had a recent stroke or TIA, does improved insulin sensitivity with pioglitazone prevent subsequent strokes or myocardial infarctions?
Does combination hormone replacement therapy in postmenopausal women decrease the risk of coronary heart disease?
Cushing’s Syndrome Review
Adrenal Incidentaloma Review