Neurology
CAPRIE
In patients with a recent CV event (stroke or MI), how does clopidogrel compare to aspirin in the secondary prevention of stroke, MI, and CV death?
PROACT II
How clinically efficacious and safe is intra-arterial recombinant prourokinase in patients with acute stroke of less than 6 hours' duration caused by MCA occlusion?
CLOSURE
In patients with cryptogenic stroke or TIA with a patent foramen ovale (PFO), does percutaneous PFO closure reduce the risk of a recurrent event?
PROFESS
Among patients with a recent ischemic stroke, how does combination aspirin-dipyridamole compare to clopidogrel in preventing recurrent stroke?
CREST
In patients with carotid artery stenosis, how does carotid artery stenting compare with carotid endarterectomy in terms of stroke, MI, and death?
PROGRESS
In patients with a history of CVA (including ischemic or hemorrhage stroke, TIA or amaurosis fugax) does the use of perindopril +/- indapamide lead to decreased risk of future stroke?
ECASS III
In patients with acute ischemic stroke, does the administration of alteplase, a tissue plasminogen activator (tPA), reduce disability at 3 months?
SPARCL
In patients with prior stroke or TIA, does high-dose atorvastatin reduce the risk of recurrent stroke?
FAST
Does recombinant activated Factor VII reduce severe disability or death in acute intracerebral hemorrhage compared to placebo?
tPA for Acute Ischemic Stroke
Does intravenous t-PA within three hours of the onset of ischemic stroke improved clinical outcome at three months?
HAEST
In patients with AF, is dalteparin safe and superior to aspirin in the prevention of recurrent strokes during the first 14 days after an acute ischemic stroke?
WARSS
In patients with a prior non-embolic ischemic stroke, is warfarin superior to ASA for secondary prevention?
MATCH
In patients with recent ischemic CVA or TIA, does clopidogrel plus aspirin reduce recurrent events when compared to clopidogrel alone?
WASID
In patients with a recent TIA or non-disabling stroke and intra-cranial artery stenosis of 50 to 99%, does medical treatment using warfarin improve mortality and decrease risk for further cerebrovascular events compared with ASA?
NASCET
In patients with symptomatic stenosis, does CEA reduce risk of death or stroke?