Antibiotics in COPD Exacerbations

    • Among outpatients with a COPD exacerbation, do antibiotics improve treatment success rates?


    • Does continuous oxygen therapy reduce mortality in patients with COPD and hypoxemia when compared to nocturnal oxygen therapy?


    • Does pirfenidone improve outcomes in IPF?


    • In patients with clinically suspected acute pulmonary embolism, what is the diagnostic accuracy of CT angiography for the diagnosis of acute pulmonary embolism?

Association Between Air Pollution and Mortality in Six US Cities

    • Does air pollution affect mortality?

Pleural Effusions: The Diagnostic Separation of Transudates and Exudates

    • How useful are the pleural-fluid protein level, the pleural-fluid LDH level, and the pleural-fluid cell counts for separating transudates from exudates?

Asthma Events with Budesonide plus Formoterol vs. Budesonide Alone

    • Is the addition of formoterol to budesonide in a fixed-dose combination was associated with a higher risk of serious asthma-related events than that with budesonide alone?


    • How do the effects of tiotropium compare with those of salmeterol on the risk of moderate and severe exacerbations?


    • Among patients with acute PE, is rivaroxaban noninferior to warfarin in preventing recurrent VTE or bleeding?

Prevention of Exacerbations of COPD with Tiotropium

    • Does tiotropium reduce exacerbations and hospitalizations due to COPD?


    • In patients with uncontrolled severe allergic asthma on inhaled corticosteroids and long-acting beta agonists, does omalizumab reduce asthma exacerbations?


    • In patients with an acute COPD exacerbation, is 5 days of glucocorticoid treatment non-inferior to 14 days of glucocorticoid treatment in preventing repeat exacerbations?


    • Did WTC exposure intensity affect pulmonary function and respiratory symptoms in an exposure intensity–response pattern after 09/11 in a FDNY cohort?


    • How effective is CPAP in reducing the rate of cardiovascular events among patients with obstructive sleep apnea?


    • Is LABA plus LAMA at least as effective as the LABA plus ICS in preventing COPD exacerbations?


    • In asthmatics, does the addition of the long-acting ß-agonist salmeterol to asthma therapy increase respiratory-related adverse events and mortality?


    • How efficacious and safe is treatment with 150 mg of nintedanib twice daily in patients with idiopathic pulmonary fibrosis?


    • In patients with COPD, what are the effects of combination therapy with salmeterol and fluticasone propionate on mortality?


    • Among patients with severe, bilateral emphysema, does lung volume reduction surgery improve survival or level of function when compared to medical therapy alone?


    • In patients with chronic obstructive pulmonary disease, is single inhaler triple therapy with beclometasone dipropionate, formoterol fumarate, and glycopyrronium bromide a safer and more effective treatment compared to beclometasone dipropionate and formoterol fumarate?


    • Among patients at high risk for lung cancer, do low-dose screening CT scans reduce mortality when compared to screening CXRs?


    • In patients with COPD, what are the effects of tioptropium on the rate of decline in lung function, exacerbations, related hospitalizations, and mortality?